Manual Surface modification technologies VIII

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View Full Details and Buy. Complementary Documents and Links:. Proceedings of the 8th International Conference, France, Subject areas: wear; advanced investigation techniques; lasers, ion beam and electron beam techniques; advanced coatings; advanced processes; modelling; thermal spraying; biomedical applications; corrosion and miscellaneous.

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Edited by: T. Browse Publishers. Top Sellers. My Account. Corporate Sustainability. Investor Relations. All Rights Reserved. Update Cart. Create New Account. The results showed that AK-VIII exhibits better performance than BSA for diminishing nonspecific adsorption of the antigen and detection antibody, thus providing lower background noise, a lower detection limit, and a wider linear range in CEA assays. The study provides a novel and versatile alternative for developing antifouling coatings to address nonspecific protein adsorption on both PDMS-based engineering and PS-based biological materials.

Book tip: Microbicides in Coatings. Please wait. This advertisement will close after 20 seconds or click here to close. This advertisement will close after 60 seconds or click here to close. Quick Links. Since the cells live and act in a 3D physiological environment in natural tissues and organs, 3D patterns on biomaterial surfaces would provide spatial architectures closed to physiological conditions and beneficial for tissue reconstruction and repair. As a result, 3D patterning technique is becoming an attractive research hotspot in the field of surface modification.

In the present review paper, 3D patterning does not refer to a specific patterning techniques, many of those described in previous sections could be used to create 3D patterns via minor modifications or by combining with other techniques.

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  4. Two-photon lithography TPL and multiphoton lithography MPL are direct-write technique that is capable of creating 3D patterns on polymeric surfaces by laser beam. During a TPL or MPL process, two-photon or multiphoton absorption occurs at a photosensitive surface by attaining energy from the laser beam, thereby chemical reactions usually polymerization take place to form 3D patterns at the laser spot. For example, Nielson et al.

    Materials and Contact Characterisation VIII

    Besides replicated patterns, crosslinked protein with unstrained structures in micro-scale could be fabricated using MPL [ ]. For biomedical applications, MPL can be used to fabricate micro-patterns or 3D structures with proteins [ — ], hydrogels [ — ], bioabsorbable polymers [ , ], gelatin [ , ] and so on. Interference lithography IL , which is also called holographic lithography or interference holography, uses interference patterns formed by two coherent laser beams to build periodic 3D patterns.

    By adjusting parameters e. During an IL process, the interfering laser beams can be used to induce polymerization reactions to create 3D patterns on a substrate. The advantage of IL is that the patterning process is simple without using masks, and the throughput is relatively higher than other patterning processes. However, the alignment of the coherent beams is complex, and any changes for the patterns need to simultaneously adjust both beams.

    Although IL was developed in recent decade and relatively widely used in the field of microelectronics or optoelectronics [ — ], this technique has also been employed to fabricate patterns on materials for biomedical applications. For example, Prodanov et al. Various surface modification techniques commonly used for bone-related implants are reviewed in this article. In practical terms, one approach would be chosen from various feasible candidates for surface modification according to the target effect and physiochemical properties of the substrate, also cost as an important factor.

    As comprehensive utilization of multiple methods is often required to fulfill the needs, it is necessary to fully understand the principles and effects of such many modification techniques, and their latest advances prior to the processing. National Center for Biotechnology Information , U. Journal List Regen Biomater v.

    Versatile antifouling coatings based on oligopeptides

    Regen Biomater. Published online Oct Author information Article notes Copyright and License information Disclaimer. Published by Oxford University Press.


    This article has been cited by other articles in PMC. Abstract At the time of implanting bone-related implants into human body, a variety of biological responses to the material surface occur with respect to surface chemistry and physical state.

    surface modification-Demonstration

    Keywords: surface modification, physicochemical coating, radiation grafting, plasma surface engineering, ion beam processing, surface patterning, bone-related materials. Introduction Biological responses to implants largely depend on the surface properties of biomaterials, such as surface chemistry and physical structure [ 1—5 ].

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    Open in a separate window. Figure 1. Surface Modification with Coating Layer Coating techniques are simple and intuitive approaches to obtain a modified surface. Rapid prototyping Rapid prototyping RP comprises a series of techniques using three-dimensional computer-aided design CAD data to quickly fabricate a model or duplicate a same part. Pulsed laser deposition Pulsed laser deposition PLD , a physical vapor deposition PVD method, is popular for fabricating calcium phosphate coating on metallic substrate, since it is able to stoichiometrically transfer material from target to substrate and could obtain a ultra-thin coating layer thickness of several atoms [ 19 ]. Figure 2. Plasma coating Plasma is a state of matter that is partially or fully ionized, and contains charged particles of free ions, electrons, radicals, as well as neutral particles of atoms and molecules. Plasma spray Plasma spray is a coating process that sprays melted or partially melted coating material onto substrate surface, and this technique has been applied to commercially available bone implants.

    Figure 3. Plasma polymerization Plasma polymerization is a process that ionizes monomer gas into plasma state and induces radical polymerization to create polymer coating on a substrate, so as to enhance corrosion resistance of metallic biomaterials or improve biocompatibility and bioactivity of relatively inert materials [ 55—57 ].

    Surface Modification with Grafting and Implantation Coating approaches can effectively modify surface properties for bone implants. Chemical covalent bonding The use of functional groups on material surface to form covalent bond between the substrate and the coating is a classical approach for constructing chemical coating. Figure 4. Photografting and radiation grafting Chemical grafting has been widely used to obtain stable surface modification results for biomaterials.

    Plasma etching and grafting Plasma can not only be used to prepare coatings on biomaterials, but is also be able to conduct various non-coating surface modification processes, for example, plasma etching and plasma grafting. Ion implantation and plasma immersion ion implantation Ion implantation Ion implantation is a physical surface modification process that injects accelerated high-energy ions into the surface of a material to modify its physicochemical and biological properties Fig. Figure 5. Surface Patterning of Biomaterials in Micro- and Nano-Scale Studies on cell biology demonstrated that the topography of the extracellular matrix ECM could regulate stem cell behaviors and fate, such as cell growth and differentiation, via physical interactions with the cells.

    Photolithography with mask Photolithography was the first surface patterning technique introduced to make patterns for controlling cell behaviors [ ]. Figure 6. Direct-write photolithography Above classic photolithography with mask is an indirect approach for the fabrication of surface patterns. Electron beam lithography With the similar principle and fabrication process to photolithography, electron beam lithography EBL is able to create nano-sized patterns on material surfaces, since the electron beam is considered as a de Broglie wave, the wavelength of the electron is much shorter than that of light beams [ ].

    Figure 7. Self-assemble of molecules or nano-particles Self-assemble is an energy-saving process to prepare patterns. Summary Various surface modification techniques commonly used for bone-related implants are reviewed in this article. References 1. High surface energy enhances cell response to titanium substrate microstructure. J Biomed Mater Res A ; 74 — Surface chemistry and biological responses to synthetic octacalcium phosphate.

    Foreign body reaction to biomaterials. Semin Immunol ; 20 — Mitragotri S, Lahann J.

    Physical approaches to biomaterial design.